Iron deficiency anaemia
IDA Ferritin: (BSG 2021 / UTD) Ferritin is the universal intracellular protein containing Iron – a soluble and non-toxic form. It is the primary iron storage protein in prokaryotes and eukaryotes. Ferritin w/o iron is called apo-ferritin . Each ferritin molecule can store up to 4,500 atoms of iron within it. Iron deficiency anaemia: 1) Low MCH is more sensitiv e for Iron deficiency than Low MCV. 2) Low Ferritin is single most important serological marker of IDA. Serum ferritin assessed by assays is usually apo-ferritin, but reflects intra-cellular ferritin stores in RES (macrophages in liver, spleen, LN etc ) in absence of inflammation. Fe < 15 – indicative of absent iron stores Fe <45 – indicative of low iron stores In anaemia of chronic disease / CHF - TSat <20% with Fe <100 is suggestive of Fe deficiency Fe > 150 unlikely ...