Hereditary Pancreatitis
Genetics / Hereditary pancreatitis Suspect if 2nd episode of 'idiopathic' acute pancreatitis in patients <40 years of age Trypsin Dependent Pathway: Trypsinogen (cationic / anionic forms) is a major protein produced in pancreas, which gets activated in dudoenum to trypsin and causes digestive proteolysis. Premature activation of Tryspin within pancreas is a major cause of development of hereditary pancreatitis. Genes: Dominant Gene: PRSS1 - Autosomal dominant, Gain of function mutation Responsible for vast majority of cases of Hereditary pancreatitis Causes ⬆⬆ cationic trypsino...