NZGG Family History Categories

 

NZGG Family History categories12

 

Category 1 - individuals with a slight increase in risk of colorectal cancer (CRC)

·         One first -degree relative diagnosed at age 55 years or over

Category 2 - individuals with a moderate increase in risk of CRC

Who have one of more of the following:

·         One first-degree relative diagnosed at age 54 years or under

·         OR

·         Two first-degree relatives on the same side of the family diagnosed at any age

Category 3 - individuals with a potentially high risk of CRC

Who have one or more of the following:

·         FAP, Lynch, other cancer syndrome

·         Three relatives with cancer: One first-degree relative plus two or more first- or second-degree relatives all on the same side of the family with a diagnosis of CRC at any age

·         Two first-degree relatives, or one first-degree relative plus one or more second degree relatives, all on the same side of the family with a diagnosis of CRC and one such relative:

o    was diagnosed with colorectal cancer aged 54 years or under, OR

o    developed multiple bowel cancers, OR

o    developed an extracolonic tumour suggestive of hereditary non-polyposis CRC (i.e., endometrial, ovarian, stomach, small bowel, renal pelvis, pancreas or brain)

·         At least one first– or second-degree family member diagnosed with CRC in association with multiple bowel polyps

·         A personal history or one first-degree relative with CRC diagnosed under the age of 50, particularly where colorectal tumour immunohistochemistry has revealed loss of protein expression for one of the mismatch repair genes (MLH1, MSH2, MSH6 and PMS2)

·         A personal history or one first-degree relative with multiple colonic polyps

 

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